A male motorcyclist has died after a head-on collision with a 4-wheel drive on the corner of Elsworth and Flockhart streets in Mt Pleasant.
Emergency services were called at 4.10pm (Thu 11 Oct 2018).
Witnesses say the rider of a blue motorbike which ended up on the side of the road was put in a neck brace as CPR was administered.
Police have confirmed the man died at the scene a short time later.
Police say it is understood the bike had been travelling east on the wrong side of the road.
The male driver of the dark coloured 4WD was uninjured and stopped to assist at the scene.
The accident happened on the corner of Flockhart St, about 50m from the scene of a house fire a week ago, where a woman's body was found.
Police say Elsworth Street has been blocked to traffic at Watson Drive and at Humffray Street..
Witnesses say bus services have also been diverted around the area.
Anyone with info should call Crimestoppers on 1800 333 000.